Total pancreatectomy with islet autotransplantation: an overview

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Is Total Pancreatectomy with Islet Autotransplantation A Reasonable Choice for Pediatric Pancreatitis?

Chronic pancreatitis is an emerging and poorly understood disease in childhood. Total pancreatectomy with islet cell autotransplantation is being proposed as a treatment for chronic pancreatitis and recent studies report a more favorable outcome in children compared to adults. Herein, we review the therapeutic alternatives for pediatric chronic pancreatitis, focusing primarily on TP/IAT.

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Glycemic Predictors of Insulin Independence After Total Pancreatectomy With Islet Autotransplantation.

Context Total pancreatectomy with islet auto transplantation (TPIAT) is a treatment for medically refractory chronic pancreatitis that can prevent postsurgical diabetes in some patients. Predictors of insulin independence are needed for appropriate patient selection and counseling. Objective To explore glycemic predictors of insulin independence after TPIAT. Design A prospective cohort of p...

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Total pancreatectomy and islet cell autotransplantation: Definitive treatment for chronic pancreatitis.

In appropriately selected patients, total pancreatectomy and islet cell autotransplant controls pain and improves quality of life while often minimizing the development of overt diabetes. Multidisciplinary management and lifelong follow-up help to maximize the benefit of this procedure. This review highlights its history, indications, metabolic outcomes, and future directions.

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Total pancreatectomy and islet cell autotransplantation: outcomes, controversies and new techniques.

Chronic pancreatitis is a challenging disease; the constellation of chronic abdominal pain and metabolic derangements present unique difficulties to the treating physician. Initial treatment revolves around lifestyle modification, pain control, and management of exocrine insufficiency. In refractory cases, total pancreatectomy with islet cell auto transplantation (TP-IAT) is an option for patie...

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Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis (Br J Surg 2012; 99: 761-766).

BACKGROUND Total pancreatectomy and islet autotransplantation (TP/IAT) is a treatment option in a subset of patients with chronic pancreatitis. A systematic review of the literature was performed to evaluate the outcome of this procedure, with an attempt to ascertain when it is indicated. METHODS MEDLINE (1950 to present), Embase (1980 to present) and the Cochrane Library were searched to ide...

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ژورنال

عنوان ژورنال: HPB

سال: 2009

ISSN: 1365-182X

DOI: 10.1111/j.1477-2574.2009.00113.x